Hospital-based surveillance for rotavirus gastroenteritis using molecular testing and immunoassay during the 2011 season in Botswana.
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Author list: Welch H, Steenhoff AP, Chakalisa U, Arscott-Mills T, Mazhani L, Mokomane M, Foster-Fabiano S, Wirth KE, Skinn A, Pernica JM, Smieja M, Goldfarb DM
Publisher: Lippincott, Williams & Wilkins
Publication year: 2013
Journal: The Pediatric Infectious Disease Journal (0891-3668)
Journal acronym: Pediatr Infect Dis J
Volume number: 32
Issue number: 5
Start page: 570
End page: 2
Number of pages: -567
ISSN: 0891-3668
eISSN: 1532-0987
Languages: English-Great Britain (EN-GB)
Abstract
We describe rotavirus testing and clinical characteristics for children admitted with acute gastroenteritis during Botswana's 2011 rotavirus season. The rotavirus season extended from June to October with rotavirus-specific case fatality being 2.8%. Using molecular testing as reference, the immunochromatographic test had a sensitivity of 76.5% and specificity of 68.0%. Rotavirus vaccine may significantly reduce childhood morbidity and mortality in Botswana.
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